Alcohol, flexible behavior, and the prefrontal cortex: Functional changes underlying impaired cognitive flexibility

Kathryn E Nippert, Courtney P. Rowland, Elena M. Vazey, David E. Moorman

Neuropharmacology, 2024

Prelimbic and infralimbic medial prefrontal cortex neuron activity signals cocaine seeking variables across multiple timescales.

David E. Moorman, Gary Aston-Jones

Psychopharmacology, vol. 240, 2023 Mar, pp. 575--594

Integration of value and action in medial prefrontal neural systems.

Beata Kaminska, Jessica P. Caballero, David E. Moorman

International review of neurobiology, vol. 158, 2021, pp. 57--82

Noradrenergic tone mediates marble burying behavior after chronic stress and ethanol.

Carolina R. den Hartog, Katrina L. Blandino, McKenzie L. Nash, Emily R. Sjogren, Michael A. Grampetro, David E. Moorman, Elena M. Vazey

Psychopharmacology, vol. 237, 2020 Oct, pp. 3021--3031

Chemogenetic Inactivation of Orbitofrontal Cortex Decreases Cue-induced Reinstatement of Ethanol and Sucrose Seeking in Male and Female Wistar Rats.

John S. Hernandez, Annalise N. Binette, Taryn Rahman, Jeffrey D. Tarantino, David E. Moorman

Alcoholism, clinical and experimental research, vol. 44, 2020 Sep, pp. 1769--1782

Orbitofrontal Cortex Encodes Preference for Alcohol.

John S. Hernandez, David E. Moorman

eNeuro, vol. 7, 2020 Aug, pp. ENEURO.0402--19.2020

Selective impact of lateral orbitofrontal cortex inactivation on reinstatement of alcohol seeking in male Long-Evans rats.

Ifeyinwa Arinze, David E. Moorman

Neuropharmacology, vol. 168, 2020 May, p. 108007

Differential Effects of Dorsal and Ventral Medial Prefrontal Cortex Inactivation during Natural Reward Seeking, Extinction, and Cue-Induced Reinstatement.

Jessica P. Caballero, Garrett B. Scarpa, Luke Remage-Healey, David E. Moorman

eNeuro, vol. 6, 2019 Oct, pp. ENEURO.0296--19.2019

Contribution of Dynorphin and Orexin Neuropeptide Systems to the Motivational Effects of Alcohol.

Rachel I. Anderson, David E. Moorman, Howard C. Becker

Handbook of experimental pharmacology, vol. 248, 2018, pp. 473--503

Central Noradrenergic Interactions with Alcohol and Regulation of Alcohol-Related Behaviors.

Elena M. Vazey, Carolina R. den Hartog, David E. Moorman

Handbook of experimental pharmacology, vol. 248, 2018, pp. 239--260

Optogenetic Dissection of Temporal Dynamics of Amygdala-Striatal Interplay during Risk/Reward Decision Making.

Debra A. Bercovici, Oren Princz-Lebel, Maric T. Tse, David E. Moorman, Stan B. Floresco

eNeuro, vol. 5, 2018 Dec

The role of the orbitofrontal cortex in alcohol use, abuse, and dependence.

David E. Moorman

Progress in neuro-psychopharmacology \& biological psychiatry, vol. 87, 2018 Dec, pp. 85--107

Phasic locus coeruleus activity regulates cortical encoding of salience information.

Elena M. Vazey, David E. Moorman, Gary Aston-Jones

Proceedings of the National Academy of Sciences of the United States of America, vol. 115, 2018 Oct, pp. E9439--E9448

The hypocretin/orexin system as a target for excessive motivation in alcohol use disorders.

David E. Moorman

Psychopharmacology, vol. 235, 2018 Jun, pp. 1663--1680

A Decade of Orexin/Hypocretin and Addiction: Where Are We Now?

Morgan H. James, Stephen V. Mahler, David E. Moorman, Gary Aston-Jones

Current topics in behavioral neurosciences, vol. 33, 2017, pp. 247--281

Stress Facilitates the Development of Cognitive Dysfunction After Chronic Ethanol Exposure.

Ellen M. Rodberg, Carolina R. den Hartog, Rachel I. Anderson, Howard C. Becker, David E. Moorman, Elena M. Vazey

Alcoholism, clinical and experimental research, vol. 41, 2017 Sep, pp. 1574--1583

Orexin/hypocretin-1 receptor antagonism reduces ethanol self-administration and reinstatement selectively in highly-motivated rats.

David E. Moorman, Morgan H. James, Elisabeth A. Kilroy, Gary Aston-Jones

Brain research, vol. 1654, 2017 Jan, pp. 34--42

A Dynamic Bayesian Model for Characterizing Cross-Neuronal Interactions During Decision-Making.

Bo Zhou, David E. Moorman, Sam Behseta, Hernando Ombao, Babak Shahbaba

Journal of the American Statistical Association, vol. 111, 2016, pp. 459--471

The highly selective orexin/hypocretin 1 receptor antagonist GSK1059865 potently reduces ethanol drinking in ethanol dependent mice.

Marcelo F. Lopez, David E. Moorman, Gary Aston-Jones, Howard C. Becker

Brain research, vol. 1636, 2016 Apr, pp. 74--80

Orexin/hypocretin neuron activation is correlated with alcohol seeking and preference in a topographically specific manner.

David E. Moorman, Morgan H. James, Elisabeth A. Kilroy, Gary Aston-Jones

The European journal of neuroscience, vol. 43, 2016 Mar, pp. 710--720

Differential roles of medial prefrontal subregions in the regulation of drug seeking.

David E. Moorman, Morgan H. James, Ellen M. McGlinchey, Gary Aston-Jones

Brain research, vol. 1628, 2015 Dec, pp. 130--146

Neural mechanisms regulating different forms of risk-related decision-making: Insights from animal models.

Caitlin A. Orsini, David E. Moorman, Jared W. Young, Barry Setlow, Stan B. Floresco

Neuroscience and biobehavioral reviews, vol. 58, 2015 Nov, pp. 147--167

Prefrontal neurons encode context-based response execution and inhibition in reward seeking and extinction.

David E. Moorman, Gary Aston-Jones

Proceedings of the National Academy of Sciences of the United States of America, vol. 112, 2015 Jul, pp. 9472--9477

Motivational activation: a unifying hypothesis of orexin/hypocretin function.

Stephen V. Mahler, David E. Moorman, Rachel J. Smith, Morgan H. James, Gary Aston-Jones

Nature neuroscience, vol. 17, 2014 Oct, pp. 1298--1303

Assessment of a proposed "three-criteria" cocaine addiction model for use in reinstatement studies with rats.

R. Parrish Waters, David E. Moorman, Amy B. Young, Matthew W. Feltenstein, Ronald E. See

Psychopharmacology, vol. 231, 2014 Aug, pp. 3197--3205

Orbitofrontal cortical neurons encode expectation-driven initiation of reward-seeking.

David E. Moorman, Gary Aston-Jones

The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 34, 2014 Jul, pp. 10234--10246

Posttraining optogenetic manipulations of basolateral amygdala activity modulate consolidation of inhibitory avoidance memory in rats.

Mary L. Huff, Rachel L. Miller, Karl Deisseroth, David E. Moorman, Ryan T. LaLumiere

Proceedings of the National Academy of Sciences of the United States of America, vol. 110, 2013 Feb, pp. 3597--3602

A rodent "self-report" measure of methamphetamine craving? Rat ultrasonic vocalizations during methamphetamine self-administration, extinction, and reinstatement.

Stephen V. Mahler, David E. Moorman, Matthew W. Feltenstein, Brittney M. Cox, Katelyn B. Ogburn, Michal Bachar, Justin T. McGonigal, Shannon M. Ghee, Ronald E. See

Behavioural brain research, vol. 236, 2013 Jan, pp. 78--89

Multiple roles for orexin/hypocretin in addiction.

Stephen V. Mahler, Rachel J. Smith, David E. Moorman, Gregory C. Sartor, Gary Aston-Jones

Progress in brain research, vol. 198, 2012, pp. 79--121

Bayesian nonparametric analysis of neuronal intensity rates.

Athanasios Kottas, Sam Behseta, David E. Moorman, Valerie Poynor, Carl R. Olson

Journal of neuroscience methods, vol. 203, 2012 Jan, pp. 241--253

Orexin/hypocretin modulates response of ventral tegmental dopamine neurons to prefrontal activation: diurnal influences.

David E. Moorman, Gary Aston-Jones

The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 30, 2010 Nov, pp. 15585--15599

Role of orexin/hypocretin in reward-seeking and addiction: implications for obesity.

Angie M. Cason, Rachel J. Smith, Pouya Tahsili-Fahadan, David E. Moorman, Gregory C. Sartor, Gary Aston-Jones

Physiology \& behavior, vol. 100, 2010 Jul, pp. 419--428

Lateral hypothalamic orexin/hypocretin neurons: A role in reward-seeking and addiction.

Gary Aston-Jones, Rachel J. Smith, Gregory C. Sartor, David E. Moorman, Lema Massi, Pouya Tahsili-Fahadan, Kimberlei A. Richardson

Brain research, vol. 1314, 2010 Feb, pp. 74--90

Orbitofrontal and insular cortex: neural responses to cocaine-associated cues and cocaine self-administration.

Karine Guillem, Alexxai V. Kravitz, David E. Moorman, Laura L. Peoples

Synapse (New York, N.Y.), vol. 64, 2010 Jan, pp. 1--13

Role of lateral hypothalamic orexin neurons in reward processing and addiction.

Gary Aston-Jones, Rachel J. Smith, David E. Moorman, Kimberlei A. Richardson

Neuropharmacology, 56 Suppl 1, 2009, pp. 112--121

Orexin-1 receptor antagonism decreases ethanol consumption and preference selectively in high-ethanol--preferring Sprague--Dawley rats.

David E. Moorman, Gary Aston-Jones

Alcohol (Fayetteville, N.Y.), vol. 43, 2009 Aug, pp. 379--386

Neuroscience: Optical control of reward.

David E. Moorman, Gary Aston-Jones

Nature, vol. 458, 2009 Apr, pp. 980--981

Testing equality of several functions: analysis of single-unit firing-rate curves across multiple experimental conditions.

Sam Behseta, Robert E. Kass, David E. Moorman, Carl R. Olson

Statistics in medicine, vol. 26, 2007 Sep, pp. 3958--3975

Combination of neuronal signals representing object-centered location and saccade direction in macaque supplementary eye field.

David E. Moorman, Carl R. Olson

Journal of neurophysiology, vol. 97, 2007 May, pp. 3554--3566

Impact of experience on the representation of object-centered space in the macaque supplementary eye field.

David E. Moorman, Carl R. Olson

Journal of neurophysiology, vol. 97, 2007 Mar, pp. 2159--2173

Session-long modulations of accumbal firing during sucrose-reinforced operant behavior.

Alexxai V. Kravitz, David E. Moorman, Alexis Simpson, Laura L. Peoples

Synapse (New York, N.Y.), vol. 60, 2006 Nov, pp. 420--428